ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer,Chemical Communications

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ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer
Chemical Communications ( IF 4.3 ) Pub Date : 2022-05-23 , DOI: 10.1039/d1cc07304d
Xin-Xin Tian ₁ , Yi-Tong Liu ₂ , Yan Li ₁ , Xin-Yu Qiu ₂ , Wen-Hua Zhang ₁ , David J Young ₃ , Qiu Chen ₁

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Introducing 2,3-dimethyl-1H-imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs ¹²⁵I₂ and the resulting radioactive host–guest complex exhibits in vitro cytotoxicity comparable to that of Na¹²⁵I against colon cancer cell line CT26.

中文翻译：

具有阳离子缺陷的 ZIF-8 可有效吸收 125I2 用于结肠癌的体外放射治疗

在 ZIF-8 的制备过程中引入 2,3-二甲基-1 H-咪唑-3-碘化物 (Dmim) 作为单齿配体产生ZIF-8 + (50)和ZIF-8 + (38)，但缺少阳离子链接器的缺陷。ZIF-8 + (38 ) 吸附¹²⁵ I ₂并且由此产生的放射性宿主-客体复合物表现出与 Na ¹²⁵ I 对结肠癌细胞系 CT26相当的体外细胞毒性。

更新日期：2022-05-23

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