甘草多糖的分离、表征、药理学和生物聚合物应用：综述,Materials

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甘草多糖的分离、表征、药理学和生物聚合物应用：综述
Materials ( IF 3.1 ) Pub Date : 2022-05-20 , DOI: 10.3390/ma15103654
Noor Ul Ain ₁ , Shuye Wu ₁ , Xiang Li ₁ , Duxin Li ₁ , Zhenqing Zhang ₁

Affiliation

甘草在中医中被称为“甘草”，属于甘草属。（科：豆科/豆科）。在我国具有悠久的药用历史和广泛的应用。甘草多糖（LPs）是关键的生物活性成分之一。随着草药多糖在过去几十年中引起越来越多的关注，它们的提取、分离、结构表征、药理活性和药用应用都得到了广泛的探索。值得注意的是，除了物种和来源特异性外，提取和纯化方法会影响 LP。本综述评估了提取和纯化的方法，并展示了其在获得特定成分方面的性能及其构效关系，这可能会为读者提供开发先进治疗策略的新视野。最近有报道称，LPs的构象作为生物聚合物起着至关重要的作用，例如硒化修饰、微胶囊化、纳米复合材料、脂质体制剂、药物/水凝胶组合、生物传感器装置以及与疫苗的协同作用。此外，LP 表现出良好的热力学特性，因为这些特性使它们能够通过化学修饰或共聚与额外的超分子相互作用相互作用。对各种外部刺激（如物理、化学和生物信号）有反应的功能聚合物是一个很有前途的研究课题。因此，LPs 正在成为一种新的生物材料，可以在发挥其固有的药用作用的同时增强预期的配方。

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Isolation, Characterization, Pharmacology and Biopolymer Applications of Licorice Polysaccharides: Review

Licorice is known as “Gan-Cao” in traditional Chinese Medicine (TCM), belonging to the genus Glycyrrhiza (Family: Fabaceae/Leguminosae). It has a long medicinal history and wide applications in China. Polysaccharides of licorice (LPs) are one of the key bioactive components. As herbal polysaccharides attracted increasing interest in the past several decades, their extraction, isolation, structural characterization, pharmacological activities, and medicinal application have been explored extensively. It is worth heeding that the method of extraction and purification effects LPs, apart from specie and origin specificity. This review evaluates the method of extraction and purification and demonstrates its performance in gaining specific composition and its structure-activity relationship, which might lead the readers to a fresh horizon for developing advanced treatment strategies. It is recently reported that the conformation of LPs plays a vital role as biopolymers, such as selenized modification, microencapsulation, nanocomposite, liposome formulation, drug/hydrogel combinations, biosensor device, and synergistic effect with a vaccine. In addition, LPs showed a good thermodynamics profile, as these properties enable them to interact with additional supramolecular interaction by chemical modifications or copolymerization. Functional polymers that are responsive to various external stimuli, such as physical, chemical, and biological signals, are a promising study topic. Thus, LPs are emerging as a new biomaterial that can enhance intended formulation along exerting its inherent medicinal effects. It is hoped that this review will provide a basis for the utilization and further developments of licorice polysaccharides in the vast medium.

更新日期：2022-05-21

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