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Advances in Protein-Based Nanocarriers of Bioactive Compounds: From Microscopic Molecular Principles to Macroscopical Structural and Functional Attributes
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-05-22 , DOI: 10.1021/acs.jafc.2c01936
Ruyi Zhang 1 , Yahong Han 2 , Weijie Xie 3 , Fuguo Liu 4 , Shuai Chen 1
Affiliation  

Many proteins can be used to fabricate nanocarriers for encapsulation, protection, and controlled release of nutraceuticals. This review examined the protein-based nanocarriers from microscopic molecular characteristics to the macroscopical structural and functional attributes. Structural, physical, and chemical properties of protein-based nanocarriers were introduced in detail. The spatial size, shape, water dispersibility, colloidal stability, etc. of protein-based nanocarriers were largely determined by the molecular physicochemical principles of protein. Different preparative techniques, including antisolvent precipitation, pH-driven, electrospray, and gelation methods, among others, can be used to fabricate different protein-based nanocarriers. Various modifications based on physical, chemical, and enzymatic approaches can be used to improve the functional performance of these nanocarriers. Protein is a natural resource with a wide range of sources, including plant, animal, and microbial, which are usually used to fabricate the nanocarriers. Protein-based nanocarriers have many advantages in aid of the application of bioactive ingredients to the medical, food, and cosmetic industries.

中文翻译:

基于蛋白质的生物活性化合物纳米载体的进展:从微观分子原理到宏观结构和功能属性

许多蛋白质可用于制造用于封装、保护和控制释放营养保健品的纳米载体。本综述从微观分子特征到宏观结构和功能属性研究了基于蛋白质的纳米载体。详细介绍了基于蛋白质的纳米载体的结构、物理和化学性质。蛋白质基纳米载体的空间大小、形状、水分散性、胶体稳定性等在很大程度上取决于蛋白质的分子理化原理。不同的制备技术,包括反溶剂沉淀、pH 驱动、电喷雾和凝胶法等,可用于制造不同的基于蛋白质的纳米载体。基于物理、化学、和酶促方法可用于改善这些纳米载体的功能性能。蛋白质是一种自然资源,来源广泛,包括植物、动物和微生物,通常用于制造纳米载体。基于蛋白质的纳米载体在帮助将生物活性成分应用于医疗、食品和化妆品行业方面具有许多优势。
更新日期:2022-05-22
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