A Büchner–Curtius–Schlotterbeck-type reaction enabled the total synthesis of tunicamycin V (TN-V), a nonselective phosphotransferase inhibitor, in just 15 steps from D-galactal in 21 % overall yield. The short and high-yielding synthetic route was also adapted for the synthesis of analogues, thus leading to the discovery of a novel cytostatic tunicamycin analogue, TN-TMPA, with high DPAGT1 selectivity.

中文翻译：

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衣霉素 V 的简明合成和细胞抑制 DPAGT1 抑制剂的发现

Büchner-Curtius-Schlotterbeck 型反应只需 15 个步骤即可从 D-半乳糖全合成衣霉素 V (TN-V)（一种非选择性磷酸转移酶抑制剂），总产率为 21%。短而高产的合成路线也适​​用于类似物的合成，从而发现了一种具有高 DPAGT1 选择性的新型细胞抑制衣霉素类似物 TN-TMPA。