当前位置：
X-MOL 学术
›
ACS Appl. Mater. Interfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Chemodynamic and Photothermal Combination Therapy Based on Dual-Modified Metal–Organic Framework for Inducing Tumor Ferroptosis/Pyroptosis
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-05-19 , DOI: 10.1021/acsami.2c00574 Huizi Deng 1 , Jun Zhang 1 , Yifan Yang 1 , Jie Yang 1 , Yawen Wei 1 , Siyu Ma 1 , Qi Shen 1
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-05-19 , DOI: 10.1021/acsami.2c00574 Huizi Deng 1 , Jun Zhang 1 , Yifan Yang 1 , Jie Yang 1 , Yawen Wei 1 , Siyu Ma 1 , Qi Shen 1
Affiliation
|
Single therapy for tumor therapy always exerts limited ability for the constraints on the reaction condition and the unavoidable multidrug resistance, which seriously influences the therapy effect in the clinic. Herein, a combination treatment nanosystem (MP@PI) based on chemodynamic therapy (CDT) and photothermal therapy (PTT) is constructed for triggering ferroptosis/pyroptosis, which is the metal–organic framework (MOF) modified with polydopamine (PDA) and IR820 to loaded with piperlongumine (PL). The MOF and PL respectively served as the iron source and H2O2 source, performing chemodynamic therapy (CDT) for eliciting ferroptosis. Meanwhile the iron source induces pyroptosis in tumor cells. PDA is not only pH responsive to release PL but also CDT-assisted which due to PDA consumes the glutathione to decrease the expression of glutathione peroxide 4. The photosensitizer IR820 exerts photothermal effects under near-infrared light and further facilitates the ferroptosis/pyroptosis. In addation, the MP@PI nanoplatform evokes the immune response in vivo and enhances the antitumor effects further. Overall, MP@PI is a kind of promising cancer therapy strategy through CDT and PTT combination, inducing ferroptosis and pyroptosis.
中文翻译：
基于双修饰金属-有机框架的化学动力学和光热联合治疗诱导肿瘤铁死亡/焦亡
肿瘤治疗的单一疗法总是由于反应条件的限制和不可避免的多药耐药能力有限，严重影响临床治疗效果。在此，构建了基于化学动力学疗法（CDT）和光热疗法（PTT）的联合治疗纳米系统（MP@PI）用于触发铁死亡/焦亡，这是用聚多巴胺（PDA）和IR820修饰的金属有机框架（MOF）装载胡椒粉（PL）。MOF和PL分别作为铁源和H 2 O 2来源，进行化学动力学疗法（CDT）以引发铁死亡。同时铁源诱导肿瘤细胞焦亡。PDA 不仅对释放 PL 有 pH 响应，而且 CDT 辅助，由于 PDA 消耗谷胱甘肽以降低过氧化谷胱甘肽 4 的表达。光敏剂 IR820 在近红外光下发挥光热效应，进一步促进铁死亡/焦亡。此外，MP@PI 纳米平台在体内引发免疫反应，进一步增强抗肿瘤作用。总体而言，MP@PI 是一种很有前景的癌症治疗策略，通过 CDT 和 PTT 组合，诱导铁死亡和焦亡。
更新日期：2022-05-19
中文翻译：
基于双修饰金属-有机框架的化学动力学和光热联合治疗诱导肿瘤铁死亡/焦亡
肿瘤治疗的单一疗法总是由于反应条件的限制和不可避免的多药耐药能力有限，严重影响临床治疗效果。在此，构建了基于化学动力学疗法（CDT）和光热疗法（PTT）的联合治疗纳米系统（MP@PI）用于触发铁死亡/焦亡，这是用聚多巴胺（PDA）和IR820修饰的金属有机框架（MOF）装载胡椒粉（PL）。MOF和PL分别作为铁源和H 2 O 2来源，进行化学动力学疗法（CDT）以引发铁死亡。同时铁源诱导肿瘤细胞焦亡。PDA 不仅对释放 PL 有 pH 响应，而且 CDT 辅助，由于 PDA 消耗谷胱甘肽以降低过氧化谷胱甘肽 4 的表达。光敏剂 IR820 在近红外光下发挥光热效应，进一步促进铁死亡/焦亡。此外，MP@PI 纳米平台在体内引发免疫反应，进一步增强抗肿瘤作用。总体而言，MP@PI 是一种很有前景的癌症治疗策略，通过 CDT 和 PTT 组合，诱导铁死亡和焦亡。
京公网安备 11010802027423号