Impact of bacterial infections and spontaneous bacterial peritonitis prophylaxis on phage-bacterial dynamics in cirrhosis,Hepatology

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Impact of bacterial infections and spontaneous bacterial peritonitis prophylaxis on phage-bacterial dynamics in cirrhosis
Hepatology ( IF 12.9 ) Pub Date : 2022-05-13 , DOI: 10.1002/hep.32571
Jasmohan S. Bajaj ₁ , Marcela Peňa Rodriguez ₂ , Andrew Fagan ₁ , Sara McGeorge ₁ , Richard K. Sterling ₁ , Hannah Lee ₁ , Velimir Luketic ₁ , Michael Fuchs ₁ , Brian C. Davis ₁ , Masoumeh Sikaroodi ₃ , Patrick M. Gillevet ₃

Affiliation

Gut microbiota, including bacteria and phages, are altered in cirrhosis, but their role during infections and spontaneous bacterial peritonitis (SBP) prophylaxis is unclear. Our aim was determine metagenomic changes in gut bacteria; phages and their linkages centered around Gram-negative and Gram-positive pathobionts in patients with cirrhosis with/without infections or SBP prophylaxis.

中文翻译：

细菌感染和自发性细菌性腹膜炎预防对肝硬化噬菌体动力学的影响

包括细菌和噬菌体在内的肠道微生物群在肝硬化中发生了改变，但它们在感染和自发性细菌性腹膜炎 (SBP) 预防中的作用尚不清楚。我们的目标是确定肠道细菌的宏基因组变化；噬菌体及其联系集中在伴有/不伴有感染或 SBP 预防的肝硬化患者中的革兰氏阴性和革兰氏阳性病原体。

更新日期：2022-05-13

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