Synthesis of Polycyclic Quinazolinones through C(sp3)−H Functionalization of Inert Alkanes or Visible-Light-Promoted Oxidation Decarboxylation of N-Hydroxyphthalimide Esters,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of Polycyclic Quinazolinones through C(sp3)−H Functionalization of Inert Alkanes or Visible-Light-Promoted Oxidation Decarboxylation of N-Hydroxyphthalimide Esters
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2022-05-19 , DOI: 10.1002/ejoc.202200523
Wei-Kang Zhang ₁ , Jiao-Zhe Li ₁ , Can-Can Zhang ₁ , Jian Zhang ₁ , Yan-Nan Zheng ₁ , Yufang Hu ₁ , Ting Li ₂ , Wen-Ting Wei ₃

Affiliation

This work describes the cleavage of the C(sp³)−H bond of inert alkanes and the visible-light promoted oxidation decarboxylation of NHP-esters to form alkyl radicals, which then efficiently synthesize valuable polycyclic quinazolinones through radical addition and cyclization. Both methods were carried out in water or water/DMSO media without metal catalysts with good functional group compatibility.

中文翻译：

通过惰性烷烃的 C(sp3)-H 官能化或可见光促进的 N-羟基邻苯二甲酰亚胺酯的氧化脱羧合成多环喹唑啉酮

这项工作描述了惰性烷烃的 C(sp ³ )-H 键的断裂和可见光促进 NHP 酯的氧化脱羧形成烷基自由基，然后通过自由基加成和环化有效合成有价值的多环喹唑啉酮。两种方法均在水或水/DMSO 介质中进行，没有金属催化剂，具有良好的官能团相容性。

更新日期：2022-05-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南