虫草素作为具有药理潜力的代谢物：综述,International Journal of Medicinal Mushrooms

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虫草素作为具有药理潜力的代谢物：综述
International Journal of Medicinal Mushrooms ( IF 1.4 ) Pub Date : 2022-01-01 , DOI: 10.1615/intjmedmushrooms.2022044442
Shivani Sharma ₁ , Kashish Madaan ₁ , Ravneet Kaur ₁

Affiliation

冬虫夏草的药理价值。与极强的生物代谢物：虫草素的存在密切相关。该成分对癌症、糖尿病和高脂血症表现出强大的治疗活性，并作为一种强大的免疫调节剂。虫草的广泛药用开发spp. 已经耗尽了它的自然存在。因此，非常需要基于代谢工程的方法，这些方法可用于过量生产所需的代谢物，从而维持市场需求。用新开发的 CRISPR 技术替代旧的传统基因组编辑工具被认为是提高代谢物产量的合适替代方案。另一种新方法 POPCORN 优化了碳/氮比率，以设计用于冬虫夏草生产的合成培养基。事实上，添加 FeSO ₄和猪肝提取物和溶解氧的改变增强了淹没状态下虫草素的产生。紫外线诱变是增强这种药学上有效的生物代谢物的另一种方法。因此，本综述的主要目的是展望虫草素的药学特性以及提高虫草素产量的代谢途径。

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Cordycepin as a Metabolite with Pharmacological Potential: A Review

The pharmacological values of Cordyceps spp. are substantially associated with the existence of an extremely potent biometabolite: cordycepin. This component exhibits powerful therapeutic activity against cancer, diabetes, and hyperlipidemia and acts as a strong immunomodulator. Extensive pharmaceutical exploitation of Cordyceps spp. has depleted its natural existence. Therefore, there is a strong need for metabolic engineering-based approaches that could be employed for overproduction of the desired metabolite, which would sustain market demands. Replacement of the old conventional genome editing tools by the newly developed CRISPR technology is considered a suitable alternative for enhancing metabolite production. Another novel approach, POPCORN, optimizes carbon/nitrogen ratios to design synthetic media for Cordyceps production. In fact, the addition of FeSO₄ and porcine liver extract and alterations in the dissolved oxygen enhanced cordycepin production in the submerged state. Ultraviolet mutagenesis is another approach for the augmentation of this pharmaceutically potent biometabolite. Therefore, the main objective of this review is to present the outlook on pharmaceutical properties of cordycepin along with the metabolic approaches for enhancing cordycepin production.

更新日期：2022-01-01

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