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Stereoselective Domino Reactions in the Synthesis of Spiro Compounds
Synthesis ( IF 2.2 ) Pub Date : 2022-02-14 , DOI: 10.1055/a-1771-0641
Regina Westphal 1 , Eclair Venturini Filho 1 , Fabrizio Medici 2 , Maurizio Benaglia 2 , Sandro Greco 1
Affiliation  

This review summarizes the latest developments in asymmetric domino reactions, with the emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the transformations, the reaction mechanisms, the rationalization of the stereochemical outcome, and the applications of domino reactions to the synthesis of biologically active molecules and natural products are included when appropriate.

1 Introduction

2 Asymmetric Domino Reactions

2.1 Domino Reactions Initiated by Michael Reactions

2.2 Domino Reactions Initiated by Mannich Reactions

2.3 Domino Reactions Initiated by Knoevenagel Reactions

2.4 Domino Reactions Initiated by Cycloaddition Reactions

2.5 Domino Reactions Initiated by Metal Insertion

2.6 Other Mechanisms

3 Conclusion



中文翻译:

螺环化合物合成中的立体选择性多米诺反应

这篇综述总结了不对称多米诺反应的最新进展,重点是螺环化合物的制备。适当时,还讨论了转化的立体选择性、反应机制、立体化学结果的合理化以及多米诺骨牌反应在生物活性分子和天然产物合成中的应用。

1 简介

2 不对称多米诺骨牌反应

2.1 Michael Reactions 发起的 Domino 反应

2.2 曼尼希反应引发的多米诺骨牌反应

2.3 Knoevenagel 反应引发的多米诺骨牌反应

2.4 环加成反应引发的多米诺骨牌反应

2.5 金属插入引发的多米诺骨牌反应

2.6 其他机制

3 结论

更新日期:2022-02-14
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