Abstract

Present work describes the T3P^® mediated one pot four component reaction between 2-aminoacetamide, methylene-active carbonyl compounds, S₈ and isothiocyantes in synthesizing 1-(3-cyanothiophen-2-yl)-3-phenylureas. The strategy developed here comprises Gewald reaction followed by the T3P intervened unique intra-molecular rearrangement. The novel and eco-friendly route achieved here is operationally facile and offers versatile 1-(3-cyanothiophen-2-yl)-3-phenylureas, which are expected to show good biological activities.

中文翻译：

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T3P® 促进了一锅多组分反应，包括独特的分子内重排

摘要

目前的工作描述了 T3P ^{®介导的 2-氨基乙酰胺、亚甲基活性羰基化合物、S} ₈和异硫氰酸酯在合成 1-(3-氰基噻吩-2-基)-3-苯基脲中的一锅四组分反应。这里开发的策略包括 Gewald 反应，然后是 T3P 干预的独特分子内重排。此处实现的新颖且环保的路线操作简便，并提供多功能的 1-(3-cyanothiophen-2-yl)-3-phenylureas，预计将显示出良好的生物活性。