As a hybrid material, metal organic frameworks (MOFs) contain unique characteristics for biomedical applications such as high porosity, large surface area, different crystalline morphologies, and nanoscale dimensions. These frameworks are assembled through the interconnection of organic linkers with metal nodes, while the engineering of an MOF for biomedical applications requires versatile linkers with acceptable symmetry. Porphyrin, as an organic linker with interesting photochemical and photophysical properties, attracted the attention of many for engineering the potent multifunctional porphyrinic metal organic frameworks (PMOFs). In this regard, a large number of approaches were conducted for designing robust practical PMOFs with a wide range of applications. In this review, we introduced another perspective of MOFs and coordination polymers constructed from porphyrinic linkers with a special focus on those synthesized by meso-tetrakis (4-carboxyphenyl) porphyrin (TCPP). In the following, we summarized and discussed the different types of PMOFs and their biomedical applications in terms of diagnostic agent, therapeutic platform, and drug delivery vehicle.

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中文翻译：

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卟啉基金属有机框架：专注于诊断和治疗应用

作为一种混合材料，金属有机框架（MOF）具有生物医学应用的独特特性，例如高孔隙率、大表面积、不同的晶体形态和纳米级尺寸。这些框架是通过有机连接体与金属节点互连组装而成，而生物医学应用的 MOF 工程需要具有可接受对称性的多功能连接体。卟啉作为一种具有有趣的光化学和光物理性质的有机连接体，因设计有效的多功能卟啉金属有机框架（PMOF）而引起了许多人的关注。在这方面，人们采取了大量的方法来设计具有广泛应用的稳健实用的 PMOF。在这篇综述中，我们介绍了由卟啉连接体构建的 MOF 和配位聚合物的另一个视角，特别关注由内消旋四（4-羧基苯基）卟啉（TCPP）合成的那些。下面，我们总结并讨论了不同类型的 PMOF 及其在诊断剂、治疗平台和药物输送载体方面的生物医学应用。

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