A set of zeolitic imidazolate framework-8 (ZIF-8) incorporated ethyl cellulose/polyvinylpyrrolidone scaffolds was prepared by electrospinning method. The impact of polyvinylpyrrolidone molecular weight on characteristics of prepared scaffolds was investigated. The ethyl cellulose/polyvinylpyrrolidone scaffold made of polyvinylpyrrolidone 17,000 showed the narrowest nanofibers (mean diameter = 140 nm), the highest percentages of porosity (62%) and swelling (>130%), the most hydrophilic surface (water contact angle = 74°), the fastest rate of degradation, and the best elongation at break (6.3%) among the samples. Furthermore, the higher capability of this scaffold for cell proliferation was revealed through MTT test (125% after 5 days of culture), Live/Dead assay, and FESEM images of cell attachment. This scaffold also represented the highest released amount of ZIF-8-induced Zn²⁺ ions (20 ppm after 84 h) leading to its greatest antibacterial activity. These findings indicated that the ZIF-8 incorporated ethyl cellulose/polyvinylpyrrolidone scaffold can be used in future skin tissue-engineered constructs.

采用静电纺丝法制备了一套掺入乙基纤维素/聚乙烯吡咯烷酮的沸石咪唑骨架8（ZIF-8）支架。研究了聚乙烯吡咯烷酮分子量对制备支架特性的影响。由聚乙烯吡咯烷酮 17,000 制成的乙基纤维素/聚乙烯吡咯烷酮支架显示出最窄的纳米纤维（平均直径 = 140 nm）、最高百分比的孔隙率（62%）和溶胀率（>130%）、最亲水的表面（水接触角 = 74° )，样品中降解速度最快，断裂伸长率最好 (6.3%)。此外，通过 MTT 测试（培养 5 天后为 125%）、活/死测定和细胞附着的 FESEM 图像，揭示了该支架对细胞增殖的更高能力。²⁺离子（84 小时后为 20 ppm）导致其最大的抗菌活性。这些发现表明，掺入 ZIF-8 的乙基纤维素/聚乙烯吡咯烷酮支架可用于未来的皮肤组织工程结构。