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The Effects of Connective Tissue Manipulation in Primary Dysmenorrhea: a Randomized Placebo-Controlled Study
Reproductive Sciences ( IF 2.6 ) Pub Date : 2022-05-13 , DOI: 10.1007/s43032-022-00964-5
Serap Özgül 1 , Gamze Nalan Çinar 1 , Ceren Gürşen 1 , Emine Baran 2 , Esra Üzelpasaci 3 , Gülbala Nakip 1 , Ege Nur Gerlegiz 1 , Şeyda Toprak Çelenay 4 , Türkan Akbayrak 1
Affiliation  

The aim of this study was to identify the effects of connective tissue manipulation (CTM) in primary dysmenorrhea (PD) in a randomized, placebo-controlled design. Thirty-eight nulliparous women with PD were randomly allocated into 3 groups: CTM (n = 13), placebo therapeutic ultrasound (US) (n = 13), and control (n = 12). The primary outcome measure was the maximum and mean menstrual pain intensity at the last menstrual period on the visual analogue scale (VAS). Secondary outcome measures were menstrual symptom frequency and distress score, the number of analgesic/anti-inflammatory drugs used during the last menstrual period, and perception of improvement in dysmenorrhea severity via interventions. The chi-square test and analysis of variance were used to determine within-group and between-group differences. Statistical significance level was determined as p < 0.05. Compared with the placebo US and control groups, it was observed that menstrual pain (VAS mean and VAS maximum), menstrual symptom frequency, and distress level decreased more after treatment (T2) and the 3-month follow-up (T3) in de CTM group (p < 0.001, p = 0.001, p = 0.014, p = 0.015, respectively). There was no difference between the groups in terms of analgesic/anti-inflammatory drugs use (p > 0.05). The rate of individuals reporting perceived improvement at the end of intervention period was higher in the CTM group than in the placebo-US and control groups (p < 0.001). In the 3rd month follow-up, there was no difference between groups in the perception of improvement (p > 0.05). CTM is superior to placebo intervention and control in improving menstrual pain and other menstrual symptoms in PD in the short-term. On the other hand, when the application is terminated, this superiority seems to disappear during the follow-up period.



中文翻译:

结缔组织治疗对原发性痛经的影响:一项随机安慰剂对照研究

本研究的目的是在随机、安慰剂对照设计中确定结缔组织操作 (CTM) 对原发性痛经 (PD) 的影响。38 名患有 PD 的初产女性被随机分配到 3 组:CTM(n  = 13)、安慰剂治疗超声(US)(n  = 13)和对照组(n = 12). 主要结果指标是视觉模拟量表 (VAS) 上末次月经时的最大和平均经痛强度。次要结果指标是月经症状频率和痛苦评分、最后一次月经期间使用的镇痛/抗炎药物的数量,以及通过干预改善痛经严重程度的感知。卡方检验和方差分析用于确定组内和组间差异。统计显着性水平确定为p  < 0.05。与安慰剂组和对照组相比,观察到月经疼痛(VAS 平均值和 VAS 最大值)、月经症状频率和痛苦程度在治疗后(T2)和 3 个月随访(T3)下降更多澳门电讯集团(p  < 0.001、p  = 0.001、p  = 0.014、p  = 0.015)。两组在镇痛/抗炎药物使用方面没有差异 ( p  > 0.05)。CTM 组在干预期结束时报告感知改善的个体比例高于安慰剂组和对照组 ( p  < 0.001)。在第 3 个月的随访中,两组对改善的看法没有差异(p > 0.05)。CTM 在短期内改善 PD 的月经疼痛和其他月经症状优于安慰剂干预和控制。另一方面,当应用程序终止时,这种优势似乎在后续期间消失了。

更新日期:2022-05-13
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