Injectable Dual-Dynamic-Bond Cross-Linked Hydrogel for Highly Efficient Infected Diabetic Wound Healing,Advanced Healthcare Materials

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Injectable Dual-Dynamic-Bond Cross-Linked Hydrogel for Highly Efficient Infected Diabetic Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-05-10 , DOI: 10.1002/adhm.202200516
Shasha Yao _{1,

2} , Yueqi Zhao _{1,

2} , Yifei Xu ₃ , Biao Jin ₄ , Monian Wang _{1,

2} , Congcong Yu _{1,

2} , Zhengxi Guo ₄ , Shengnan Jiang ₅ , Ruikang Tang ₄ , Xiangqian Fang _{1,

2} , Shunwu Fan _{1,

2}

Affiliation

Diabetic wound is a significant challenge for clinical treatment with high morbidity and mortality. Plenty of hydrogels with good biocompatibility have been widely used in diabetic wound healing. However, most of them cannot be directly absorbed and utilized by the wounds, which prolongs the regeneration time. Here a new type of healing hydrogel is developed that is based on histidine, a natural dietary essential amino acid that is significant for tissue formation. The amino acid is cross-linked with zinc ions (Zn²⁺) and sodium alginate (SA) via dynamic coordinate and hydrogen bonds, respectively, forming a histidine-SA-Zn²⁺ (HSZH) hydrogel with good injectable, adhesive, biocompatible, and antibacterial properties. Application of this dual-dynamic-bond cross-linked HSZH hydrogel accelerates the migration and angiogenesis of skin-related cells in vitro. Furthermore, it significantly promotes the healing of infected diabetic wounds in vivo and uniquely allows a full repair of wounds within ≈13 days, while ≈27 days are required for the healing process of the control group. This work provides a new strategy for designing wound dressing materials, that weakly cross-linked material based on tissue-friendly micromolecules can heal the wounds more efficiently than highly cross-linked materials based on long-chain polymers.

中文翻译：

可注射的双动态键交联水凝胶，用于糖尿病感染伤口的高效愈合

糖尿病伤口的高发病率和死亡率是临床治疗的一个重大挑战。大量具有良好生物相容性的水凝胶已广泛用于糖尿病伤口愈合。但大部分不能直接被伤口吸收利用，延长了再生时间。这里开发了一种基于组氨酸的新型愈合水凝胶，组氨酸是一种对组织形成具有重要意义的天然膳食必需氨基酸。氨基酸分别通过动态配位键和氢键与锌离子（Zn ²⁺）和海藻酸钠（SA）交联，形成组氨酸-SA-Zn ²⁺(HSZH) 水凝胶具有良好的可注射性、粘合性、生物相容性和抗菌性。这种双动态键交联 HSZH 水凝胶的应用加速了体外皮肤相关细胞的迁移和血管生成。此外，它显着促进体内感染的糖尿病伤口的愈合，并且独特地允许在约 13 天内完全修复伤口，而对照组的愈合过程需要约 27 天。这项工作为设计伤口敷料材料提供了一种新策略，即基于组织友好型小分子的弱交联材料比基于长链聚合物的高度交联材料可以更有效地治愈伤口。

更新日期：2022-05-10

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