The theory of constructed emotion is a systems neuroscience approach to understanding the nature of emotion. It is also a general theoretical framework to guide hypothesis generation for how actions and experiences are constructed as the brain continually anticipates metabolic needs and attempts to meet those needs before they arise (termed allostasis). In this review, we introduce this framework and hypothesize that allostatic dysregulation is a trans-disorder vulnerability for mental and physical illness. We then review published findings consistent with the hypothesis that several symptoms in major depressive disorder (MDD), such as fatigue, distress, context insensitivity, reward insensitivity, and motor retardation, are associated with persistent problems in energy regulation. Our approach transforms the current understanding of MDD as resulting from enhanced emotional reactivity combined with reduced cognitive control and, in doing so, offers novel hypotheses regarding the development, progression, treatment, and prevention of MDD.

中文翻译：

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抑郁症中的失恋、行动和情感：来自建构情绪理论的见解


构建情绪理论是一种理解情绪本质的系统神经科学方法。它也是一个通用的理论框架，用于指导关于如何构建行动和体验的假设生成，因为大脑不断预测新陈代谢需求并试图在它们出现之前满足这些需求（称为 allostasis）。在这篇综述中，我们介绍了这个框架，并假设同种异体失调是精神和身体疾病的反式障碍脆弱性。然后，我们回顾了已发表的研究结果，该假设与重度抑郁症 （MDD） 中的几种症状一致，例如疲劳、痛苦、环境不敏感、奖励不敏感和运动迟缓，与能量调节的持续问题有关。我们的方法改变了目前对 MDD 的理解，即情绪反应性增强与认知控制减少相结合，并在此过程中提供了关于 MDD 的发展、进展、治疗和预防的新假设。