Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis, controllable structure, biocompatibility, biomimetic viscoelastic mechanical behavior, and functional groups available for modification. In recent years, various multifunctional designs and biomedical applications, including cardiovascular, orthopedic, muscle tissue, skin tissue, nerve and spinal cord, bioimaging, and drug or gene delivery based on citrate-based polymers, have been extensively studied, and many of them have good clinical application potential. In this review, we summarize recent progress in the multifunctional design and biomedical applications of citrate-based polymers. We also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications.

开发具有高度可控功能的生物活性生物材料对于增强其在再生医学中的应用至关重要。柠檬酸盐基聚合物由于其合成简便、结构可控、生物相容性好、仿生粘弹性力学行为和可用于修饰的官能团等优点，成为生物医学中使用的少数生物活性聚合物生物材料。近年来，各种多功能设计和生物医学应用得到了广泛的研究，包括心血管、骨科、肌肉组织、皮肤组织、神经和脊髓、生物成像以及基于柠檬酸盐聚合物的药物或基因传递。具有良好的临床应用潜力。在这篇综述中，我们总结了柠檬酸盐聚合物多功能设计和生物医学应用的最新进展。