Safe treatment of antibiotics requires efficient removal of both antibiotics and their degraded intermediates. In this study, we demonstrate that FeC₂O₄•2H₂O enables the more sustainable conversion of H₂O₂ to ^•OH than commonly used FeSO₄•7H₂O, promoting the detoxification of a typical antibiotic sulfadimidine. It was found that the FeC₂O₄/H₂O₂ system could completely degrade 250 mg L⁻¹ of sulfadimidine within 40 min at pH 3.0, along with decreasing the contents of chemical oxygen demand and total organic carbon by 295.0 and 33.5 mg L⁻¹, respectively, more efficient than those in a classical Fenton system (FeSO₄/H₂O₂). Analysis of sulfadimidine degraded intermediates and toxicity evaluation suggested that the FeC₂O₄/H₂O₂ treatment could more effectively decrease the overall toxicity of the sulfadimidine solution than the FeSO₄/H₂O₂ counterpart. The sustainability of FeC₂O₄•2H₂O in H₂O₂ conversion to ^•OH was attributed to its controlled release of Fe²⁺ into the solution to prevent the quenching of ^•OH by excessive Fe²⁺, as well as the simultaneous release of C₂O₄²⁻ to complex with Fe²⁺ and Fe³⁺, which could inhibit iron sludge formation and accelerate Fe³⁺/Fe²⁺ redox cycle. This study provides a promising Fenton system for the safe treatment of antibiotics and sheds light on the potential of FeC₂O₄•2H₂O in environmental remediation.

抗生素的安全处理需要有效去除抗生素及其降解的中间体。在本研究中，我们证明与常用的 FeSO ₄ •7H _{2 O 相比，FeC 2} O ₄ •2H ₂ O 能够更可持续地将 H ₂ O ₂转化为^• OH ，从而促进典型抗生素磺胺嘧啶的解毒。发现FeC ₂ O ₄ /H ₂ O ₂体系可以完全降解250 mg L ^-1在 pH 3.0 条件下，40 分钟内完成磺胺脒，同时化学需氧量和总有机碳含量分别降低 295.0 和 33.5 mg L ^-1，比经典 Fenton 体系（FeSO ₄ /H ₂ O ₂）。磺胺嘧啶降解中间体的分析和毒性评价表明，与FeSO ₄ /H ₂ O ₂对应物相比，FeC ₂ O ₄ /H ₂ O ₂处理可以更有效地降低磺胺嘧啶溶液的总体毒性。FeC ₂ O ₄ •2H的可持续性H 2 O 2 中的₂ O_转化为• ^OH的原因在于其将 Fe ²⁺控制释放到溶液中以防止过量的 Fe ^2+对• OH 的猝灭，以及同时释放 C ₂ O ₄ ^2-与Fe ²⁺和Fe ³⁺络合，可抑制铁泥形成，加速Fe ³⁺ /Fe ²⁺氧化还原循环。该研究为安全治疗抗生素提供了一个很有前景的 Fenton 系统，并揭示了 FeC ₂ O ₄ •2H _2的潜力O 在环境修复中。