加入碘化钠提高乳牙补牙材料的生物学作用,Molecules

当前位置： X-MOL 学术 › Molecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

加入碘化钠提高乳牙补牙材料的生物学作用
Molecules ( IF 4.2 ) Pub Date : 2022-05-04 , DOI: 10.3390/molecules27092927
Ji-Myung Choi ₁ , Huong Thu Vu ₂ , Seong-Jin Shin ₂ , Jun-Yong Ahn ₃ , You-Jin Kim ₃ , Sol Song ₁ , Mi-Ran Han ₁ , Jun-Haeng Lee ₁ , Jong-Soo Kim ₁ , Jonathan C Knowles _{2,

4,

5,

6,

7,

8} , Hae-Hyoung Lee _{2,

3,

4,

5} , Ji-Sun Shin ₁ , Jong-Bin Kim ₁ , Jung-Hwan Lee _{2,

3,

4,

5,

6,

9}

Affiliation

Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Cell & Matter Institute, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK.
The Discoveries Centre for Regenerative and Precision Medicine, Eastman Dental Institute, University College London, Gower Street, London WC1E 6BT, UK.
Mechanobiology Dental Medicine Research Center, Dankook University, 119 Dand-ro, Cheonan 31116, Korea.

治疗性碘仿（CHI ₃) 通常用作乳牙的牙根填充材料；然而，已经报道了含碘仿材料的副作用，包括早期根吸收。为了克服这个问题，开发了一种掺入水溶性碘化物（NaI）的根填充材料。氢氧化钙、硅油和NaI以不同的重量比（30:30:X）掺入，所得材料表示为DX（D5~D30），表示NaI含量。作为对照，碘仿代替 NaI 以 30:30:30 的比例掺入，材料表示为 I30。测定了物理化学（流量、膜厚度、射线不透性、粘度、吸水性、溶解度和离子释放）和生物学（细胞毒性、TRAP、ARS 和破骨细胞标志物分析）特性。碘、钠的含量，D30中钙离子释放量和pH值均高于I30，I30中检测到的未知提取分子含量最高。在细胞活力测试中，除 100% D30 外的所有组均未显示细胞毒性。在 50% 无毒提取物中，与 I30 相比，D30 显示破骨细胞形成减少。总之，与碘仿材料相比，掺入 NaI 的材料表现出足够的物理化学性质和较低的破骨细胞形成。因此，在进一步（预）临床研究后，掺入 NaI 的材料可用作根填充材料中碘仿对应物的替代品。与 I30 相比，D30 显示破骨细胞形成减少。总之，与碘仿材料相比，掺入 NaI 的材料表现出足够的物理化学性质和较低的破骨细胞形成。因此，在进一步（预）临床研究后，掺入 NaI 的材料可用作根填充材料中碘仿对应物的替代品。与 I30 相比，D30 显示破骨细胞形成减少。总之，与碘仿材料相比，掺入 NaI 的材料表现出足够的物理化学性质和较低的破骨细胞形成。因此，在进一步（预）临床研究后，掺入 NaI 的材料可用作根填充材料中碘仿对应物的替代品。

"点击查看英文标题和摘要"

Improvement of Biological Effects of Root-Filling Materials for Primary Teeth by Incorporating Sodium Iodide

Therapeutic iodoform (CHI₃) is commonly used as a root-filling material for primary teeth; however, the side effects of iodoform-containing materials, including early root resorption, have been reported. To overcome this problem, a water-soluble iodide (NaI)-incorporated root-filling material was developed. Calcium hydroxide, silicone oil, and NaI were incorporated in different weight proportions (30:30:X), and the resulting material was denoted DX (D5~D30), indicating the NaI content. As a control, iodoform instead of NaI was incorporated at a ratio of 30:30:30, and the material was denoted I30. The physicochemical (flow, film thickness, radiopacity, viscosity, water absorption, solubility, and ion releases) and biological (cytotoxicity, TRAP, ARS, and analysis of osteoclastic markers) properties were determined. The amount of iodine, sodium, and calcium ion releases and the pH were higher in D30 than I30, and the highest level of unknown extracted molecules was detected in I30. In the cell viability test, all groups except 100% D30 showed no cytotoxicity. In the 50% nontoxic extract, D30 showed decreased osteoclast formation compared with I30. In summary, NaI-incorporated materials showed adequate physicochemical properties and low osteoclast formation compared to their iodoform-counterpart. Thus, NaI-incorporated materials may be used as a substitute for iodoform-counterparts in root-filling materials after further (pre)clinical investigation.

更新日期：2022-05-04

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南