Synthesis of functionalized γ-lactams by a lewis acid catalyzed ketene formation/cyclization/claisen rearrangement sequence of 5,5-disubstituted Meldrum’s acid,Tetrahedron Letters

当前位置： X-MOL 学术 › Tetrahedron Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of functionalized γ-lactams by a lewis acid catalyzed ketene formation/cyclization/claisen rearrangement sequence of 5,5-disubstituted Meldrum’s acid
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2022-04-30 , DOI: 10.1016/j.tetlet.2022.153816
Xiao-Wan Lin ₁ , Mei Han ₁ , Mei-Hua Shen ₁ , Chi-Fan Zhu ₁ , Hua-Dong Xu ₁

Affiliation

A series of γ-lactams were synthesized by intramolecular aza-claisen rearrangement of ketenes using Meldrum’s acid as ketene precursor. Derivatives of Meldrum’s acid with tertiary ammonia structure were used as raw material, and the reaction was catalyzed by Lewis acid at high-temperature conditions under microwave. Ketene formation by losing acetone and CO₂, cyclization and claisen rearrangement occurred in sequence to form the γ-lactams.

中文翻译：