Enantioselective Cobalt-Catalyzed Hydroboration of Ketone-Derived Silyl Enol Ethers,Angewandte Chemie International Edition

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Enantioselective Cobalt-Catalyzed Hydroboration of Ketone-Derived Silyl Enol Ethers
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-04-29 , DOI: 10.1002/anie.202117413
Wenke Dong ₁ , Zhiyang Ye ₁ , Wanxiang Zhao ₁

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The catalytic asymmetric hydroboration of heteroatom-substituted alkenes is rarely explored and remains unprecedented, especially the earth-abundant metal catalyzed ones. Herein, the first cobalt-catalyzed asymmetric hydroboration of ketone-derived silyl enol ethers is reported, providing a convenient approach to access valuable enantiopure β-hydroxy boronic esters, which features broad substrate scope and excellent enantioselectivities.

中文翻译：

酮衍生甲硅烷基烯醇醚的对映选择性钴催化硼氢化

杂原子取代烯烃的催化不对称硼氢化反应很少被探索并且仍然是前所未有的，尤其是地球上丰富的金属催化的。本文报道了第一次钴催化的酮衍生甲硅烷基烯醇醚的不对称硼氢化反应，为获得有价值的对映纯 β-羟基硼酸酯提供了一种便捷的方法，该方法具有广泛的底物范围和优异的对映选择性。

更新日期：2022-04-29

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