The reaction of 4-oxahomoadamantan-5-one with hydrazine gave (3-exo,7-endo)-7-hydroxybicyclo[3.3.1]nonane-3-carbohydrazide. The latter was reacted with benzonitrile, formamide, and p-(trifluoromethyl)benzaldehyde to obtain a number of new bicyclo[3.3.1]nonane derivatives. The structural features of the new compounds were studied using 2D NMR spectroscopy and XRD analysis. The synthesized bicyclo[3.3.1]nonanes can be used in the directed synthesis of compounds of high molecular complexity for biological activity testing.

中文翻译：

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7-羟基双环[3.3.1]壬烷-3-碳酰肼的合成及化学转化

4-oxahomoadamantan-5-one 与肼反应得到 (3-exo,7-endo)-7-羟基双环[3.3.1]nonane-3-carbohydrazide。后者与苯甲腈、甲酰胺和对-(三氟甲基)苯甲醛反应得到许多新的双环[3.3.1]壬烷衍生物。使用 2D NMR 光谱和 XRD 分析研究了新化合物的结构特征。合成的双环[3.3.1]壬烷可用于生物活性检测的高分子复杂化合物的定向合成。