A New Synthesis of Phenolic 1-Hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines,Heterocycles

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A New Synthesis of Phenolic 1-Hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
Heterocycles ( IF 0.8 ) Pub Date : 2005-01-01 , DOI: 10.3987/com-05-10554
Masaru Kihara , Motoki Ikeuchi , Miyuki Ikeuchi , Kumiko Inoue , Syuhei Yamamoto , Aiko Yamauchi

7,8-Dihydroxy-1-phenyl- and 1-(3- and 4-hydroxyphenyl)-1-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives (2a,b) and (3a-c) were synthesized by intramolecular Barbier reaction of N-(2-iodophenethyl)-phenacylamines (5a,b) and (12a-c) with n-C 4 H 9 Li as a key reaction step.

中文翻译：

酚醛1-羟基-1-苯基-2,3,4,5-四氢-1H-3-苯并氮杂的新合成

7,8-二羟基-1-苯基-和 1-(3-和 4-羟基苯基)-1-羟基-2,3,4,5-四氢-1H-3-苯并氮杂衍生物 (2a,b) 和 (3a -c) 是通过 N-(2-碘苯乙基)-苯乙胺 (5a,b) 和 (12a-c) 与 nC 4 H 9 Li 的分子内巴比尔反应作为关键反应步骤合成的。

更新日期：2005-01-01

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