In this study, gelatin microdroplets were generated using a PDMS square microchannel (100 ×100 µm). The flow regime map was experimentally determined, and the regimes in which is possible to obtain microdroplets, dripping and jetting, were studied in detail. The regime map was compared with maps published in the literature and it was found that the regime map depends significantly on the viscosity ratio. For each regime, a correlation to calculate the normalized size of the droplet was obtained by fitting the experimental data. The smaller microdroplets obtained a size of 53 µm and 60 µm, for dripping and jetting regimes, respectively. The droplets generated in this microfluidic device were collected and gelled. We concluded that occurred a decrease in the size of the final microparticle during the curing process. A coefficient of variation (CV - %) between 2% and 4% was found for the microdroplets and microparticles, which demonstrates that this method can be used to produce monodispersed gelatin microparticles.

在本研究中，使用 PDMS 方形微通道 (100 ×100  µm) 生成明胶微滴。流态图是通过实验确定的，并详细研究了可能获得微滴、滴落和喷射的流态。将状态图与文献中发表的图进行比较，发现状态图显着取决于粘度比。对于每个方案，通过拟合实验数据获得了计算液滴归一化尺寸的相关性。较小的微滴尺寸为 53  µm 和 60 µm，分别用于滴水和喷射状态。在该微流体装置中产生的液滴被收集并胶凝。我们得出结论，在固化过程中最终微粒的尺寸发生了减小。发现微滴和微粒的变异系数（CV - %）在 2% 和 4% 之间，这表明该方法可用于生产单分散明胶微粒。