Ferroptosis is defined as an iron-dependent, non-apoptotic cell death pathway, with specific morphological phenotypes and biochemical changes. There is a growing realization that ferroptosis has significant implications for several neurodegenerative diseases. Even though ferroptosis is different from other forms of programmed death such as apoptosis and autophagic death, they involve a number of common protein molecules. This review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis, apoptosis, and autophagy that are implicated in neurodegenerative diseases. We hope that this information provides new ideas for understanding the mechanisms and searching for potential therapeutic approaches and prevention of neurodegenerative diseases.

铁死亡被定义为一种铁依赖性、非凋亡性细胞死亡途径，具有特定的形态表型和生化变化。人们越来越认识到铁死亡对多种神经退行性疾病具有重大影响。尽管铁死亡与其他形式的程序性死亡（例如细胞凋亡和自噬性死亡）不同，但它们涉及许多常见的蛋白质分子。本文重点介绍了铁死亡的最新研究，并总结了神经退行性疾病中铁死亡、细胞凋亡和自噬之间的相互作用。我们希望这些信息为理解神经退行性疾病的机制、寻找潜在的治疗方法和预防提供新的思路。