Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer,Journal of the American Chemical Society

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Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2022-04-27 , DOI: 10.1021/jacs.2c02976
Renyu Guo ₁ , Yu-Che Chang ₁ , Loic Herter _{2,

3} , Christophe Salome ₂ , Sarah E Braley ₁ , Thomas C Fessard ₂ , M Kevin Brown ₁

Affiliation

Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vectors, yet many substitution patterns are underexplored as building blocks. The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. The scope and mechanistic details of the method are discussed.

中文翻译：

由能量转移引发的应变释放 [2π + 2σ] 环加成合成双环[2.1.1]己烷

饱和自行车在新药物的设计和开发中变得越来越重要。这里描述了一种合成双环[2.1.1]己烷的新策略。这些自行车很重要，因为它们定义了退出向量，但许多替代模式作为构建块尚未得到充分探索。该过程涉及双环[1.1.0]丁烷的敏化，然后与烯烃进行环加成。讨论了该方法的范围和机制细节。

更新日期：2022-04-27

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