Cobalt-Catalyzed Four-Component Carbonylation of Methylarenes with Ethylene and Alcohols,The Journal of Organic Chemistry

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Cobalt-Catalyzed Four-Component Carbonylation of Methylarenes with Ethylene and Alcohols
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-04-25 , DOI: 10.1021/acs.joc.2c00008
Jian-Xing Xu ₁ , Chang-Sheng Kuai ₁ , Xiao-Feng Wu _{1,

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Affiliation

Direct conversion of raw materials to fine chemicals is greatly economically influential. We developed a non-expensive cobalt-catalyzed multicomponent carbonylative reaction for the synthesis of γ-aryl carboxylic acid esters from readily available methylarene, ethylene, and CO, which are widely found in multiple FDA-approved drugs.

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