1H-Indole-3-carbaldehyde and related members of the indole family are ideal precursors for the synthesis of active molecules. 1H-Indole-3-carbaldehyde and its derivatives are essential and efficient chemical precursors for generating biologically active structures. Multicomponent reactions (MCRs) offer access to complex molecules. This review highlights the recent applications of 1H-indole-3-carbaldehyde in such inherently sustainable multicomponent reactions from the period, 2014 to 2021 and provides an overview of the field that awaits further exploitation in the assembly of pharmaceutically interesting scaffolds.

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中文翻译：

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1H-吲哚-3-甲醛衍生物的分子多样性及其在多组分反应中的作用

1 H -Indole-3-carbaldehyde 和吲哚家族的相关成员是合成活性分子的理想前体。1 H -Indole-3-carbaldehyde 及其衍生物是产生生物活性结构的重要且有效的化学前体。多组分反应 (MCR) 提供了对复杂分子的访问。本综述重点介绍了 2014 年至 2021 年期间 1 H-吲哚-3-甲醛在这种固有的可持续多组分反应中的最新应用，并概述了在组装药学上感兴趣的支架方面有待进一步开发的领域。

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