Sodium bromate is a powerful brominating agent for aromatic compounds that contain deactivating substituents. A bromination process, in which sodium bromate was utilized, was optimized on laboratory scale. Addition of a strong acid into a stirred aqueous solution, or slurry, of the substrate and bromate salt at 40−100°C, leads to the decomposition of the bromate ions and production of the active brominating species. Substrates such as nitrobenzene, benzoic acid, and benzaldehyde were brominated in high yields (85−98%) and specificity. The reaction is especially useful for the bromination of disubstituted benzenes, such as 4-nitrofluorobenzene or 4-fluorobenzoic acid. Several substrates, such as dinitrobenzenes or nitrobenzoic acids, did not undergo bromination at all. The main parameters of the reaction and some of its synthetic potential are discussed.

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溴酸钠在芳香族溴化中的用途：研究与开发

溴酸钠是一种强效溴化剂，适用于含有失活取代基的芳香族化合物。在实验室规模上优化了使用溴酸钠的溴化工艺。在 40-100°C 下将强酸添加到搅拌的底物和溴酸盐的水溶液或浆液中，会导致溴酸盐离子分解并产生活性溴化物质。硝基苯、苯甲酸和苯甲醛等底物以高产率 (85-98%) 和特异性溴化。该反应特别适用于溴化二取代苯，例如 4-硝基氟苯或 4-氟苯甲酸。几种底物，例如二硝基苯或硝基苯甲酸，根本没有发生溴化。