A process for the preparation of matrix metalloproteinase inhibitor ABT-518 has been developed. Significant improvements have been made to the first generation synthesis and are described here. The new process is very robust and efficient; multikilogram quantities of the title compound have been synthesized for clinical trials. ABT-518 was prepared by this six-step synthetic sequence in 51% overall yield with >99% ee.

中文翻译：

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大规模合成基质金属蛋白酶抑制剂 ABT-518

已经开发了一种制备基质金属蛋白酶抑制剂 ABT-518 的方法。对第一代合成进行了重大改进，并在此处进行了描述。新流程非常稳健和高效；已合成数公斤量的标题化合物用于临床试验。ABT-518 通过这个六步合成序列以 51% 的总产率和 >99% 的 ee 制备。