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4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium Chloride (DMTMM): A Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis
Synlett ( IF 1.7 ) Pub Date : 2000-02-01 , DOI: 10.1055/s-2000-6490 Alessandro Falchi , Giampaolo Giacomelli , Andrea Porcheddu , Maurizio Taddei
Synlett ( IF 1.7 ) Pub Date : 2000-02-01 , DOI: 10.1055/s-2000-6490 Alessandro Falchi , Giampaolo Giacomelli , Andrea Porcheddu , Maurizio Taddei
The salt formed from 2-chloro-4,6-dimethoxy[1,3,5]triazine and N-methylmorpholine (DMTMM) is an effective coupling agent for solid phase peptide synthesis that can be used as economical alternative to PyBOP. Several oligopeptides were prepared on a Wang type resin using this reagent and the yields and purity of the products were always comparable with those obtained with PyBOP as the coupling agent.
中文翻译:
4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium Chloride (DMTMM):PyBOP 固相肽合成的有价值替代品
由 2-氯-4,6-二甲氧基[1,3,5]三嗪和 N-甲基吗啉 (DMTMM) 形成的盐是用于固相肽合成的有效偶联剂,可用作 PyBOP 的经济替代品。使用该试剂在 Wang 型树脂上制备了几种寡肽,产品的产率和纯度始终与使用 PyBOP 作为偶联剂获得的产品相当。
更新日期:2000-02-01
中文翻译:
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4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium Chloride (DMTMM):PyBOP 固相肽合成的有价值替代品
由 2-氯-4,6-二甲氧基[1,3,5]三嗪和 N-甲基吗啉 (DMTMM) 形成的盐是用于固相肽合成的有效偶联剂,可用作 PyBOP 的经济替代品。使用该试剂在 Wang 型树脂上制备了几种寡肽,产品的产率和纯度始终与使用 PyBOP 作为偶联剂获得的产品相当。