tert-Butoxycarbonyl chloride (BocCI) can be generated in situ from tert-butyl alcohol, COCl 2 , and pyridine at -74 °C to introduce the Boc group in high yield into a hindered amino acid. The method is suitable for large-scale preparations of Boc-amino acids.

中文翻译：

---

用于将 N-Boc 基团引入氨基酸的叔丁氧羰基氯

叔丁氧羰基氯 (BocCl) 可以在 -74 °C 下由叔丁醇、COCl 2 和吡啶原位生成，从而以高产率将 Boc 基团引入受阻氨基酸中。该方法适用于Boc-氨基酸的大规模制备。