A regioselective and highly efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones is presented. In situ generated propiolic acid chloride was used for the cyclization of acyclic β-keto N,S-acetals to afford the heterocyclic core. Substitution by amines led to a flexible access of the target compounds.

中文翻译：

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利用原位生成的丙炔酸氯化物高效合成 6-氨基取代吡啶-2(1H)-ones

提出了一种区域选择性和高效合成 6-氨基取代的 pyridin-2(1H)-ones。原位生成的丙炔酰氯用于环化无环 β-酮基 N,S-缩醛以提供杂环核。胺取代导致目标化合物的灵活访问。