A novel method for the introduction of fluorine in the purine 2-position is described and employed in the synthesis of a potential antimycobacterial compound. Also 2-fluoroadenosine has been synthesized for the first time from adenosine with perbenzoylated 2-nitroadenosine as a key intermediate. Mild reaction conditions are employed and few synthetic steps are required. The novel synthesis of fluoroadenosine can be regarded as a formal synthesis of the antileukemic drug fludarabine phosphate.

中文翻译：

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一种将氟引入嘌呤 2 位的新方法：2-氟腺苷的合成和抗白血病药物氟达拉滨的正式合成

描述了一种在嘌呤 2 位引入氟的新方法，并将其用于合成潜在的抗分枝杆菌化合物。此外，以过苯甲酰化2-硝基腺苷为关键中间体，首次从腺苷合成2-氟腺苷。采用温和的反应条件，只需要很少的合成步骤。氟腺苷的新合成可以看作是抗白血病药物磷酸氟达拉滨的正式合成。