Photocaging of Activity-Based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy,Angewandte Chemie International Edition

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Photocaging of Activity-Based Ubiquitin Probes via a C-Terminal Backbone Modification Strategy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-04-23 , DOI: 10.1002/anie.202203792
Yu Wang _{1,

2,

3} , Jingnan Chen ₁ , Xiao Hua ₃ , Xianbin Meng ₄ , Hongyi Cai ₂ , Rongtian Wang ₁ , Jing Shi ₃ , Haiteng Deng ₄ , Lei Liu ₂ , Yi-Ming Li ₁

Affiliation

Photocaged cell-permeable Ub-PA and diUb-Dha probes that can be activated on demand to label DUBs in vivo have been developed using a C-terminal backbone modification strategy. These new Ub-ABPs are temporally blocked and activated through installing a light-sensitive group (e.g. nitrobenzyl) at the backbone amide bond of the Ub Gly75 residue.

中文翻译：

通过 C 端骨干修饰策略对基于活动的泛素探针进行光笼化

已使用 C 末端骨架修饰策略开发了可按需激活以在体内标记 DUB 的光笼式细胞渗透性 Ub-PA 和 diUb-Dha 探针。这些新的 Ub-ABP 通过在 Ub Gly75 残基的主链酰胺键上安装一个光敏基团（例如硝基苄基）被暂时阻断和激活。

更新日期：2022-04-23

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