Photoinduced Chemo-, Site- and Stereoselective α-C(sp3)−H Functionalization of Sulfides,Angewandte Chemie International Edition

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Photoinduced Chemo-, Site- and Stereoselective α-C(sp3)−H Functionalization of Sulfides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-04-20 , DOI: 10.1002/anie.202203374
Zhenda Tan _{1,

2} , Shibo Zhu ₂ , Yangbin Liu ₂ , Xiaoming Feng _{2,

3}

Affiliation

A photoinduced chemo-, site- and stereoselective α-C(sp³)−H functionalization of sulfides was demonstrated using isatins as the photoredox reagent and coupling partner catalyzed by a chiral gallium(III)-N,N′-dioxide complex. This cross-coupling protocol is highly selective for the direct late-stage functionalization of methionine-related peptides, regardless of the inherent structural similarity and complexity of diverse residues.

中文翻译：

硫化物的光诱导化学选择性、位点选择性和立体选择性α-C(sp3)-H 官能化

使用靛红作为光氧化还原试剂和由手性镓 (III) -N,N'-二氧化物复合物催化的偶联配偶体，证明了硫化物的光诱导化学选择性、位点选择性和立体选择性α -C(sp ^{3 )-H 官能化。}这种交叉偶联方案对于蛋氨酸相关肽的直接后期功能化具有高度选择性，无论不同残基的固有结构相似性和复杂性如何。

更新日期：2022-04-20

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