A Platelet-Mimicking Single-Atom Nanozyme for Mitochondrial Damage-Mediated Mild-Temperature Photothermal Therapy,ACS Applied Materials & Interfaces

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A Platelet-Mimicking Single-Atom Nanozyme for Mitochondrial Damage-Mediated Mild-Temperature Photothermal Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-04-20 , DOI: 10.1021/acsami.1c22346
Pengyuan Qi ₁ , Junyu Zhang ₁ , Zhirong Bao ₂ , Yuanping Liao ₁ , Zeming Liu ₂ , Jike Wang ₁

Affiliation

Single-atom nanozyme (SAzyme) systems have shown great potential in tumor therapy. A multifunctional SAzyme not only possesses high catalytic activity but also can be used as photothermal agents in photothermal therapy (PTT). Furthermore, it is also imperative to overcome tumor thermal resistance in SAzyme-based PTT so that PTT under a mild temperature is achievable. Herein, a novel platelet membrane (PM)-coated mesoporous Fe single-atom nanozyme (Fe-SAzyme) was formulated to solve these issues. The PM-coated mesoporous Fe-SAzyme (PMS) showed a satisfactory NIR-II photothermal performance, high peroxidase (POD) activity, and good tumor-targeting ability. In addition, PMS may be used as a carrier for protein drugs owing to its inner mesoporous structure. In vitro experiments showed that PMS could inhibit the expression of heat shock protein (HSP) by damaging the mitochondria, thereby finally improving the effect of mild-temperature PTT. Moreover, in vivo results showed that PMS could efficiently accumulate in tumor sites and suppress tumor growth with minimal toxicity in major organs. To the best of our knowledge, this study is the first report of a biomimetic mesoporous Fe-SAzyme used to achieve mitochondrial damage-mediated mild-temperature PTT. The study provides new promising ideas for designing other SAzyme systems for cancer treatment.

中文翻译：

用于线粒体损伤介导的温和光热疗法的血小板模拟单原子纳米酶

单原子纳米酶（SAzyme）系统在肿瘤治疗中显示出巨大的潜力。一种多功能的SAzyme不仅具有高催化活性，而且可以用作光热疗法（PTT）中的光热剂。此外，还必须克服基于 SAzyme 的 PTT 中的肿瘤耐热性，以便在温和的温度下实现 PTT。为了解决这些问题，本文研制了一种新型的血小板膜（PM）包覆的介孔铁单原子纳米酶（Fe-SAzyme）。PM 包覆的介孔 Fe-SAzyme (PMS) 表现出令人满意的 NIR-II 光热性能、高过氧化物酶 (POD) 活性和良好的肿瘤靶向能力。此外，由于其内部的介孔结构，PMS可用作蛋白质药物的载体。体外实验表明，PMS可以通过破坏线粒体来抑制热休克蛋白（HSP）的表达，从而最终提高温和PTT的效果。此外，体内结果表明，PMS 可以有效地积聚在肿瘤部位并抑制肿瘤生长，而对主要器官的毒性最小。据我们所知，本研究首次报道了一种用于实现线粒体损伤介导的温和温度 PTT 的仿生介孔 Fe-SAzyme。该研究为设计其他用于癌症治疗的 SAzyme 系统提供了新的有希望的想法。

更新日期：2022-04-20

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