A series of imidazopyrazine derivatives were synthesized, in which compound A1 showed the strongest anti-inflammatory activity in vitro and in vivo. The EC₅₀ of the activity inhibition rate of compound A1 was lower than that of the positive control, and the toxicity of compound A1 was less than that of dexamethasone as a whole.

中文翻译：

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咪唑并吡嗪作为新的抗炎剂：体外和体内的发现和生物活性研究

合成了一系列咪唑并吡嗪衍生物，其中化合物A1在体外和体内均表现出最强的抗炎活性。化合物A1的活性抑制率EC ₅₀低于阳性对照，且化合物A1的毒性总体上小于地塞米松。