地塞米松：药理学方面、治疗机制和给药系统的见解,ACS Biomaterials Science & Engineering

当前位置： X-MOL 学术 › ACS Biomater. Sci. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

地塞米松：药理学方面、治疗机制和给药系统的见解
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2022-04-19 , DOI: 10.1021/acsbiomaterials.2c00026
Vijay Sagar Madamsetty ₁ , Reza Mohammadinejad ₂ , Ilona Uzieliene ₃ , Noushin Nabavi ₄ , Ali Dehshahri ₅ , Jomarien García-Couce _{6,

7} , Shima Tavakol ₈ , Saeid Moghassemi ₉ , Arezoo Dadashzadeh ₉ , Pooyan Makvandi _{10,

11} , Abbas Pardakhty ₁₂ , Abbas Aghaei Afshar ₂ , Ali Seyfoddin ₁₃

Affiliation

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, Florida 32224, United States.
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7618866749, Iran.
Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu 5, LT-08406 Vilnius, Lithuania.
Department of Urologic Sciences, Vancouver Prostate Centre, Vancouver, British Columbia, Canada V6H 3Z6.
Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz 7146864685, Iran.
Department of Radiology, Division of Translational Nanobiomaterials and Imaging, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Department of Polymeric Biomaterials, Biomaterials Center (BIOMAT), University of Havana, Havana 10600, Cuba.
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 1417755469, Iran.
Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels 1200, Belgium.
Istituto Italiano di Tecnologia, Centre for Micro-BioRobotics, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.
Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran 14496-14535, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7618866748, Iran.
Drug Delivery Research Group, Auckland University of Technology (AUT), School of Science, Auckland 1010, New Zealand.

地塞米松 (DEX) 已广泛用于治疗多种疾病，包括自身免疫性疾病、过敏、眼部疾病、癌症以及最近的 COVID-19。然而，DEX由于其水溶性差，在临床上的使用常常受到限制。当通过全身途径给药时，它会引起严重的副作用，例如高血压、消化性溃疡、高血糖和水电解质紊乱。目前，人们对开发有效的 DEX 纳米制剂非常感兴趣，这种制剂可以改善抑制科学研究进步的不良疾病影响。近年来，已经开发出各种纳米颗粒来选择性地递送药物而不破坏健康细胞或器官。在本综述中，我们总结了 DEX 负载递送系统的一些最有吸引力的应用，包括脂质体、聚合物、水凝胶、纳米纤维、二氧化硅、磷酸钙和羟基磷灰石。这篇综述为我们的读者提供了广泛的纳米医学方法来安全地提供 DEX。

"点击查看英文标题和摘要"

更新日期：2022-04-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南