益生菌和合生元消耗对最普遍的化疗相关并发症的影响：当前文献的系统评价。,Current medicinal chemistry

当前位置： X-MOL 学术 › Curr Med Chem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

益生菌和合生元消耗对最普遍的化疗相关并发症的影响：当前文献的系统评价。
Current medicinal chemistry Pub Date : 2022-01-01 , DOI: 10.2174/0929867329666220415114343
Arman Arab ₁ , Elham Karimi _{2,

3} , Mohammad Bagherniya _{4,

5,

6} , Thozhukat Sathyapalan ₇ , Amirhossein Sahebkar _{8,

9,

10,

11}

Affiliation

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Medicine, The University of Western Australia, Perth, Australia.
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

背景迄今为止，许多研究已经使用益生元/合生元来检查它们对化疗相关副作用的影响。然而，他们的研究结果尚无定论。为了解决这个问题，我们使用随机对照试验 (RCT) 进行了一项系统评价，以探索益生元/合生元消耗对化疗相关副作用的影响，包括成人的恶心、呕吐、粘膜炎、腹泻和便秘。方法从最早可用日期到 2021 年 3 月，系统地搜索了包括 PubMed、Scopus 和 ISI Web of Sciences 在内的电子数据库，以确定符合条件的研究。基于 Cochrane Collaboration Risk of Bias 工具评估纳入研究的质量。结果本次系统评价共纳入 10 项研究，涉及 788 人，样本量为 25 至 200 人，平均年龄为 51.04 至 66.91 岁。这项研究的结果表明，与其他并发症相比，食用益生菌在治疗粘膜炎方面可能更有效。结论需要更多具有更好方法学的高质量随机对照试验来确定益生元/合生元是否以及如何预防或治疗化疗引起的副作用。目前的系统评价结果可能有助于未来研究的调查人员选择研究人群和益生菌菌株。结论需要更多具有更好方法学的高质量随机对照试验来确定益生元/合生元是否以及如何预防或治疗化疗引起的副作用。目前的系统评价结果可能有助于未来研究的调查人员选择研究人群和益生菌菌株。结论需要更多具有更好方法学的高质量随机对照试验来确定益生元/合生元是否以及如何预防或治疗化疗引起的副作用。目前的系统评价结果可能有助于未来研究的调查人员选择研究人群和益生菌菌株。

"点击查看英文标题和摘要"

The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature.

BACKGROUND To date, many investigations have employed pro-/synbiotic to examine their effects on chemotherapy-related side effects; nevertheless, their findings are inconclusive. To address this issue, we carried out a systematic review to explore the effect of pro- /synbiotic consumption on chemotherapy-related side effects, including nausea, vomiting, mucositis, diarrhea, and constipation in adults using randomized controlled trials (RCTs). METHODS The electronic databases, including PubMed, Scopus, and ISI Web of Sciences, were searched systematically from the earliest available date to March 2021 to identify eligible studies. The quality of the enrolled studies was assessed based on the Cochrane Collaboration Risk of Bias tool. RESULTS A total of 10 studies involving 788 individuals were included in the current systematic review, with the sample size ranging from 25 to 200 and the mean age ranging from 51.04 to 66.91 years. The findings of this study imply that probiotic consumption may be more effective in terms of mucositis compared to other complications. CONCLUSION Further good-quality RCTs with better methodology are required to determine whether and how pro-/synbiotics can prevent or treat chemotherapy-induced side effects. The current systematic review findings may help investigators of future studies in selecting the study population and probiotic strains.

更新日期：2022-04-15

点击分享查看原文

点击收藏

全部期刊列表>>