Zoxamide is a benzamide fungicide applied to control diseases caused by oomycete fungi. Fertilizers are important agricultural supplies to adjust soil properties and increase nutrition. To investigate the impact of zoxamide and seven fertilizers urea, phosphate fertilizer, potash fertilizer, compound fertilizer, organic fertilizer, vermicompost and soya bean cakes on the soil environment, the enantioselective dissipation characteristics of zoxamide, soil enzyme activities, pH and N, P nutrition changes were comprehensively analyzed in our present study. The enantioseparation method was successfully validated to quantify the zoxamide enantiomers in soil by HPLC using Chiral NQ (2)-RH column. Our results demonstrated that the R-(−)- and S-(+)-zoxamide half dissipated in the range of 10.88–17.81 and 8.05–14.41 days, respectively. S-(+)-zoxamide disappeared faster in soil. The vermicompost accelerated the dissipation rate of S-(+)-zoxamide, while urea, phosphate, organic and vermicompost fertilizer increased the dissipation selectivity. Zoxamide and fertilizers other than urea caused soil acidification during 80 days. Zoxamide was beneficial to soil catalase, instead inhibited soil urease, dehydrogenase activities and available phosphorus content. No significant effects on sucrase activity and available nitrogen content were found by zoxamide. Vermicompost and soya bean cakes had lasting and outstanding performance in efficiently improving soil enzyme activity and N, P nutrition. The comprehensive understanding of the ecological impact induced by chiral pesticide enantiomers and fertilizers on soil is vital to ensure the sustainable development and safety of agricultural production.

Zoxamide是一种苯甲酰胺类杀菌剂，用于防治由卵菌引起的疾病。化肥是调整土壤性质和增加营养的重要农业供应品。探讨三唑草胺及七肥尿素、磷肥、钾肥、复合肥、有机肥、蚯蚓粪和豆饼对土壤环境的影响、三唑草胺的对映选择性消散特性、土壤酶活性、pH和N、P营养在我们目前的研究中对变化进行了全面分析。使用手性 NQ (2)-RH 柱通过 HPLC 对对映体分离方法进行了成功验证，以量化土壤中的唑菌胺对映异构体。我们的结果表明，R -(-)- 和S -(+) -唑沙胺的一半分别在 10.88-17.81 和 8.05-14.41 天范围内消散。S -(+)-zoxamide 在土壤中消失得更快。蚯蚓堆肥加速了S的消散速度-(+)-zoxamide，而尿素、磷酸盐、有机肥和蚯蚓肥增加了消散选择性。Zoxamide 和除尿素以外的肥料在 80 天内导致土壤酸化。唑草胺对土壤过氧化氢酶有益，而对土壤脲酶、脱氢酶活性和速效磷含量有抑制作用。唑草胺对蔗糖酶活性和有效氮含量没有显着影响。蚯蚓粪和豆饼在有效提高土壤酶活性和N、P营养方面具有持久而突出的表现。全面了解手性农药对映体和化肥对土壤的生态影响对于确保农业生产的可持续发展和安全至关重要。