The homoleptic trifluoromethyl nickel complex [Ni(CF₃)₄]²⁻ catalyzes a stereoselective trifluoromethylation of brucine with Umemoto II reagent. The trifluoromethylation process proceeds with concomitant isomerization of its alkenyl double bond leading to a trifluoromethylated neobrucine-like derivative. A minor difunctionalization product was also detected from the reaction mixture, consistent with a radical addition process that is occurring in parallel. Stoichiometric reactions between the nickel(II) catalyst precursor and brucine led to no reaction. However, a stochiometric reaction with a high-valent nickel(IV) complex formed trifluoromethylated neobrucine, implicating its intermediacy.

均配三氟甲基镍络合物 [Ni(CF ₃ ) ₄ ] ^2-用 Umemoto II 试剂催化马钱子碱的立体选择性三氟甲基化。三氟甲基化过程伴随其烯基双键的异构化而进行，产生三氟甲基化的新布鲁辛样衍生物。还从反应混合物中检测到少量双官能化产物，这与平行发生的自由基加成过程一致。镍 (II) 催化剂前体和马钱子碱之间的化学计量反应没有导致反应。然而，与高价镍 (IV) 配合物的化学计量反应形成了三氟甲基化的新布鲁辛，暗示了它的中间体。