Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells,Thoracic Cancer

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Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells
Thoracic Cancer ( IF 2.3 ) Pub Date : 2022-04-15 , DOI: 10.1111/1759-7714.14400
Aiying Xue ₁ , Yue Shang ₁ , Peng Jiao ₂ , Songling Zhang ₁ , Changchun Zhu ₁ , Xin He ₁ , Guoxing Feng ₁ , Saijun Fan ₁

Affiliation

Radiotherapy is an effective therapeutic approach widely used clinically in non-small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA-sensing cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has become an attractive therapeutic target, but the relationship between activation of cGAS-STING pathway and radiosensitization of NSCLC cells remains unknown.

中文翻译：

cGAS-STING通路的激活增加增强了非小细胞肺癌细胞的放射敏感性

放射治疗是临床上广泛用于非小细胞肺癌（NSCLC）的有效治疗方法，但放射抗性仍然是主要挑战。因此迫切需要新的和有效的放射增敏方法。DNA 感应环 GMP-AMP 合酶 (cGAS)-干扰素基因刺激物 (STING) 通路的激活已成为一个有吸引力的治疗靶点，但 cGAS-STING 通路的激活与 NSCLC 细胞放射增敏之间的关系仍不清楚。

更新日期：2022-04-15

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