Isoquinoline alkaloids are a large group of natural products in which 1,2,3,4-tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic compounds exert diverse biological activities against various infective pathogens and neurodegenerative disorders. Due to these reasons, the THIQ heterocyclic scaffold has garnered a lot of attention in the scientific community which has resulted in the development of novel THIQ analogs with potent biological activity. The present review provides a much-needed update on the biological potential of THIQ analogs, their structural-activity relationship (SAR), and their mechanism of action. In addition, a note on commonly used synthetic strategies for constructing the core scaffold has also been discussed.

中文翻译：

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1,2,3,4-四氢异喹啉类似物的药物化学观点 - 生物活性和 SAR 研究。

异喹啉生物碱是一大类天然产物，其中 1,2,3,4-四氢异喹啉 (THIQ) 是一个重要类别。基于 THIQ 的天然和合成化合物对各种感染性病原体和神经退行性疾病具有多种生物活性。由于这些原因，THIQ 杂环支架在科学界引起了广泛关注，从而开发了具有强大生物活性的新型 THIQ 类似物。本综述提供了关于 THIQ 类似物的生物学潜力、它们的结构-活性关系 (SAR) 及其作用机制的急需更新。此外，还讨论了有关构建核心支架的常用合成策略的说明。