A-DA′D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy,ACS Applied Materials & Interfaces

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A-DA′D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2022-04-14 , DOI: 10.1021/acsami.1c22444
Ke Yang ₁ , Fei Long ₂ , Wei Liu ₁ , Zequn Zhang ₂ , Shaojing Zhao ₁ , Benhua Wang ₁ , Yingping Zou ₁ , Minhuan Lan ₁ , Jun Yuan ₁ , Xiangzhi Song ₁ , Changwei Lin ₂

Affiliation

Multimodal imaging-guided combinational phototherapies triggered by a single near-infrared (NIR) laser are highly desirable. However, their development is still a big challenge. Herein, we have developed an “acceptor–donor–acceptor′–donor–acceptor” structured organic phototheranostics (Y16-Pr) with strong light-harvesting ability in the NIR region. After being modified with polyethylene glycol (PEG), the obtained biocompatible nanoparticles (Y16-Pr-PEG NPs) could conduct NIR-II fluorescence imaging (FLI) and photoacoustic imaging (PAI) and perform photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Notably, Y16-Pr-PEG NPs showed an impressive photothermal conversion efficiency (PCE) of 82.4% under 808 nm laser irradiation. The irradiated NPs could also produce hydroxyl radicals (•OH) and singlet oxygen (¹O₂) for type I and type II PDT, respectively. In vivo and in vitro experiments revealed that the Y16-Pr-PEG NPs significantly inhibit tumor cell growth without apparent toxic side effects under laser irradiation. Overall, the single-laser-triggered multifunctional phototheranostic Y16-Pr-PEG NPs can achieve NIR-II FLI/PAI-guided synergistic PTT/PDT against tumors.

中文翻译：

用于 NIR-II 荧光/光声成像引导的光热和光动力协同治疗的 A-DA'DA 结构化有机光治疗

由单个近红外 (NIR) 激光触发的多模式成像引导的组合光疗是非常可取的。然而，它们的发展仍然是一个很大的挑战。在此，我们开发了一种“受体-供体-受体'-供体-受体”结构的有机光疗（Y16-Pr），在近红外区域具有很强的光捕获能力。得到的生物相容性纳米粒子（Y16-Pr-PEG NPs）经聚乙二醇（PEG）修饰后，可以进行 NIR-II 荧光成像（FLI）和光声成像（PAI）以及光热疗法（PTT）和光动力疗法（PDT））同时地。值得注意的是，Y16-Pr-PEG NPs 在 808 nm 激光照射下显示出令人印象深刻的 82.4% 的光热转换效率 (PCE)。辐照的 NPs 还可以产生羟基自由基 (•OH) 和单线态氧 (¹ O ₂ ) 分别用于 I 型和 II 型 PDT。体内和体外实验表明，Y16-Pr-PEG NPs 在激光照射下可显着抑制肿瘤细胞生长，且无明显毒副作用。总体而言，单激光触发的多功能光疗 Y16-Pr-PEG NPs 可以实现 NIR-II FLI/PAI 引导的协同 PTT/PDT 对抗肿瘤。

更新日期：2022-04-14

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