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A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride
Synthetic Communications ( IF 1.8 ) Pub Date : 2022-04-11 , DOI: 10.1080/00397911.2022.2047731 Avula Mahesh Kumar 1 , Rapolu Venkateshwarlu 1, 2 , Krishnaji Tadiparthi 3 , B. Venkateswara Rao 4 , Shiva Kumar Kota Balaji 1 , Akula Raghunadh 1 , Shambhu Nath Singh 1
中文翻译：
(2S,5S)-5-羟基哌可酸盐酸盐的简便合成新方法
更新日期：2022-04-11
Synthetic Communications ( IF 1.8 ) Pub Date : 2022-04-11 , DOI: 10.1080/00397911.2022.2047731 Avula Mahesh Kumar 1 , Rapolu Venkateshwarlu 1, 2 , Krishnaji Tadiparthi 3 , B. Venkateswara Rao 4 , Shiva Kumar Kota Balaji 1 , Akula Raghunadh 1 , Shambhu Nath Singh 1
Affiliation
Abstract
A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride is reported. The key features of the synthesis involve the asymmetric reduction of ketone using (S)-CBS oxazaborolidine and the use of commercially available methyl pyroglutamate as a starting material.
中文翻译：
(2S,5S)-5-羟基哌可酸盐酸盐的简便合成新方法
摘要
报道了一种简单高效的(2 S ,5 S )-5-羟基哌可酸盐酸盐合成方法。该合成的关键特征包括使用 ( S )-CBS 恶唑硼烷对酮进行不对称还原，并使用市售的焦谷氨酸甲酯作为起始材料。
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