叶黄素、玉米黄质和内消旋玉米黄质的黄斑色素膳食补充剂会影响认知吗？,Journal of Alzheimer’s Disease

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叶黄素、玉米黄质和内消旋玉米黄质的黄斑色素膳食补充剂会影响认知吗？
Journal of Alzheimer’s Disease ( IF 3.4 ) Pub Date : 2022-04-11 , DOI: 10.3233/jad-215736
Hongwei Wang ₁ , Ge Wang ₂ , Rebecca Billings ₃ , Daniel Li ₄ , Shakaye R Haase ₅ , Pariya F Wheeler _{5,

6} , David E Vance _{5,

6} , Wei Li ₇

Affiliation

背景：叶黄素（L）、玉米黄质（Z）和内消旋玉米黄质（MZ）统称为黄斑色素。MZ 可以从黄斑中的 L 转换而来。在最近十年中，已经进行了许多研究来调查服用类胡萝卜素，特别是 L 和 Z 或 L、Z 和 MZ，作为膳食补充剂对人类健康的影响。目的：我们检查了 L + Z 或 L + Z + MZ 的膳食补充剂是否对成人的认知功能有影响。方法：2021年3月进行系统文献检索，关键词为：叶黄素、玉米黄质、中玉米黄质、认知、认知和黄斑色素。搜索的数据库包括 Medline EBSCOhost、Scopus、Elsevier、Cochrane Library、ProQuest 和 ClinicalTrials.gov。八项临床试验的结果作为研究主题的最有力证据提出。结果：大多数研究发现，血液或黄斑中的黄斑色素（L + Z）与认知能力呈正相关。作为大脑中黄斑色素数量的指标，黄斑色素光密度与成人的认知能力有关。此外，血液中黄斑色素含量较高与轻度认知障碍或阿尔茨海默病风险较低之间存在反比关系。根据临床试验的结果，L + Z 或 L + Z + MZ 的膳食补充剂与成人认知能力的改善有关。结论：L+Z或L+Z+MZ的膳食补充剂与更好的认知功能相关，这可能是通过它们对视力的有益影响。作为大脑中黄斑色素数量的指标，黄斑色素光密度与成人的认知能力有关。此外，血液中黄斑色素含量较高与轻度认知障碍或阿尔茨海默病风险较低之间存在反比关系。根据临床试验的结果，L + Z 或 L + Z + MZ 的膳食补充剂与成人认知能力的改善有关。结论：L+Z或L+Z+MZ的膳食补充剂与更好的认知功能相关，这可能是通过它们对视力的有益影响。作为大脑中黄斑色素数量的指标，黄斑色素光密度与成人的认知能力有关。此外，血液中黄斑色素含量较高与轻度认知障碍或阿尔茨海默病风险较低之间存在反比关系。根据临床试验的结果，L + Z 或 L + Z + MZ 的膳食补充剂与成人认知能力的改善有关。结论：L+Z或L+Z+MZ的膳食补充剂与更好的认知功能相关，这可能是通过它们对视力的有益影响。血液中黄斑色素含量较高与轻度认知障碍或阿尔茨海默病风险较低之间存在反比关系。根据临床试验的结果，L + Z 或 L + Z + MZ 的膳食补充剂与成人认知能力的改善有关。结论：L+Z或L+Z+MZ的膳食补充剂与更好的认知功能相关，这可能是通过它们对视力的有益影响。血液中黄斑色素含量较高与轻度认知障碍或阿尔茨海默病风险较低之间存在反比关系。根据临床试验的结果，L + Z 或 L + Z + MZ 的膳食补充剂与成人认知能力的改善有关。结论：L+Z或L+Z+MZ的膳食补充剂与更好的认知功能相关，这可能是通过它们对视力的有益影响。

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Can Diet Supplements of Macular Pigment of Lutein, Zeaxanthin, and Meso-zeaxanthin Affect Cognition?

Background:Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are collectively called macular pigment. MZ can be converted from L in the macula. In the recent decade, many studies have been performed to investigate the effects for taking carotenoids, especially L and Z or L, Z, and MZ, as diet supplements on human health. Objective:We examined if diet supplements of L + Z or L + Z + MZ have effects on cognitive function in adults. Methods:A systemic literature search was performed in March 2021 with the following keywords: lutein, zeaxanthin, meso-zeaxanthin, cognition, cognitive, and macular pigment. The searched databases included Medline EBSCOhost, Scopus, Elsevier, Cochrane Library, ProQuest, and ClinicalTrials.gov. Findings from eight clinical trials were presented as the strongest evidence on the studied topic. Results:Most studies have found that macular pigments (L + Z) in blood or macula are positively correlated with cognitive performance. As an index of the amount of macular pigments in the brain, macular pigment optical density is related to cognitive performance in adults. In addition, there is an inverse relationship between a higher amount of macular pigment in the blood and lower risk of mild cognitive impairments or Alzheimer’s disease. Based on the findings from the clinical trials, diet supplements of L + Z or L + Z + MZ are associated with improved cognition in adults. Conclusion:The diet supplements of L + Z or L + Z+MZ are associated with better cognitive functioning, which may be via their beneficial effects on the vision.

更新日期：2022-04-11

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