Administration of xylo-oligosaccharides improves depressive-like behaviour in mice caused by chronic unpredictable mild stress by altering microbiota composition,International Journal of Food Science & Technology

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Administration of xylo-oligosaccharides improves depressive-like behaviour in mice caused by chronic unpredictable mild stress by altering microbiota composition
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2022-04-09 , DOI: 10.1111/ijfs.15745
Xiangling Shu ₁ , Yanjun Tong ₁ , Ruijin Yang _{1,

2}

Affiliation

Xylo-oligosaccharides (XOS) is a functional oligosaccharide with prebiotic properties, and could be fermented by gut microbiota. In this study, the modulatory effects of XOS on emotions and behaviours at different dose were investigated based on the mouse model of chronic unpredictable mild stress-induced depression. The result showed that 0.23 and 0.50 g kg⁻¹ doses of XOS significantly increased sucrose preference index and decreased the immobility time in tail suspension and forced swimming tests. Meanwhile, the dose of 0.23 g kg⁻¹ day⁻¹ XOS significantly increased the concentration of neurotransmitters, such as 5-hydroxytryptamine and γ- aminobutyric acid. Furthermore, the analysis of the faecal microbiota with XOS intervention showed a higher relative abundance of Akkermansia, Bifidobacterium and Lactobacillus, fewer Desulfovibrio and the SCFA concentrations increased with XOS prevention treatment. These results suggested that the dietary supplementation XOS could improve chronic stress-induced depressive-like behaviour by modulating neurotransmitters and reverting gut microbiota changes in mice. These findings present XOS as a potential prebiotic targeting to the gut microbiota for mood disorders.

中文翻译：

施用低聚木糖可通过改变微生物群组成来改善由慢性不可预测的轻度压力引起的小鼠抑郁样行为

低聚木糖 (XOS) 是一种具有益生元特性的功能性低聚糖，可被肠道微生物群发酵。本研究基于慢性不可预知的轻度应激性抑郁症小鼠模型，研究了不同剂量XOS对情绪和行为的调节作用。结果表明，0.23 和 0.50 g kg ^-1剂量的 XOS 显着增加了蔗糖偏好指数，并减少了悬尾和强迫游泳试验中的不动时间。同时，剂量为 0.23 g kg ^-1 天^-1XOS显着增加了神经递质的浓度，例如5-羟色胺和γ-氨基丁酸。此外，通过 XOS 干预对粪便微生物群的分析表明，随着 XOS 预防治疗，阿克曼氏菌、双歧杆菌和乳杆菌的相对丰度较高，脱硫弧菌较少，SCFA 浓度增加。这些结果表明，膳食补充剂 XOS 可以通过调节神经递质和恢复小鼠肠道微生物群的变化来改善慢性压力诱导的抑郁样行为。这些发现表明 XOS 作为一种潜在的益生元靶向肠道微生物群以治疗情绪障碍。

更新日期：2022-04-09

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