The solubility of methyl 1,2,4-triazole-3-carboxylate in 14 solvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutyl alcohol, acetonitrile, acetone, 2-pentanone, 3-pentanone, 4-methyl-2-pentanone, cyclopentanone, cyclohexanone, tetrahydrofuran) in the range from 278.15 to 318.15 K and at atmospheric pressure was measured in this study. The solubility of methyl 1,2,4-triazole-3-carboxylate in all solvents increases with the increasing temperature. The solubility of methyl 1,2,4-triazole-3-carboxylate in the solvents except for methanol and cyclohexanone does not show much difference, and is significantly smaller than that in methanol and cyclohexanone. The solubility of methyl 1,2,4-triazole-3-carboxylate is not strictly related to polarity of the solvents as it is to the existence of other factors. The solubility of methyl 1,2,4-triazole-3-carboxylate was correlated by the λh equation, modified Apelblat model, and Yaws model. The Yaws model is the best one among the three models with average relative deviation (ARD) and average root-mean-square deviation (10⁴(RMSD)) of 1.18% and 0.364. The work in this study provides important solubility data for purification and synthesis of methyl 1,2,4-triazole-3-carboxylate.

中文翻译：

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1,2,4-三唑-3-甲酸甲酯在 278.15 至 318.15 K 的 14 种纯溶剂中溶解度的测量和相关性

1,2,4-三唑-3-羧酸甲酯在 14 种溶剂（甲醇、乙醇、1-丙醇、2-丙醇、1-丁醇、异丁醇、乙腈、丙酮、2-戊酮、3-戊酮、在本研究中测量了 278.15 至 318.15 K 和大气压下的 4-甲基-2-戊酮、环戊酮、环己酮、四氢呋喃）。1,2,4-三唑-3-羧酸甲酯在所有溶剂中的溶解度随着温度的升高而增加。1,2,4-三唑-3-羧酸甲酯在除甲醇和环己酮以外的溶剂中的溶解度没有太大差异，明显小于在甲醇和环己酮中的溶解度。1,2,4-三唑-3-羧酸甲酯的溶解度与溶剂的极性没有严格的关系，因为它与其他因素的存在有关。甲基1,2的溶解度，h方程、修正的 Apelblat 模型和 Yaws 模型。Yaws 模型是三个模型中最好的一个，平均相对偏差 (ARD) 和平均均方根偏差 (10 ⁴ (RMSD)) 分别为 1.18% 和 0.364。本研究工作为 1,2,4-三唑-3-羧酸甲酯的纯化和合成提供了重要的溶解度数据。