Intelligent Micro-/Nanorobots for Cancer Theragnostic,Advanced Materials

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Intelligent Micro-/Nanorobots for Cancer Theragnostic
Advanced Materials ( IF 27.4 ) Pub Date : 2022-04-06 , DOI: 10.1002/adma.202201051
Jie Wang ₁ , Yue Dong ₁ , Peng Ma ₁ , Yu Wang ₁ , Fangyu Zhang ₂ , Bocheng Cai ₃ , Peng Chen ₁ , Bi-Feng Liu ₁

Affiliation

Cancer is one of the most intractable diseases owing to its high mortality rate and lack of effective diagnostic and treatment tools. Advancements in micro-/nanorobot (MNR)-assisted sensing, imaging, and therapeutics offer unprecedented opportunities to develop MNR-based cancer theragnostic platforms. Unlike ordinary nanoparticles, which exhibit Brownian motion in biofluids, MNRs overcome viscous resistance in an ultralow Reynolds number (Re << 1) environment by effective self-propulsion. This unique locomotion property has motivated the advanced design and functionalization of MNRs as a basis for next-generation cancer-therapy platforms, which offer the potential for precise distribution and improved permeation of therapeutic agents. Enhanced barrier penetration, imaging-guided operation, and biosensing are additionally studied to enable the promising cancer-related applications of MNRs. Herein, the recent advances in MNR-based cancer therapy are comprehensively addresses, including actuation engines, diagnostics, medical imaging, and targeted drug delivery; promising research opportunities that can have a profound impact on cancer therapy over the next decade is highlighted.

中文翻译：

用于癌症治疗的智能微/纳米机器人

癌症由于其高死亡率和缺乏有效的诊断和治疗工具而成为最难治的疾病之一。微/纳米机器人 (MNR) 辅助传感、成像和治疗的进步为开发基于 MNR 的癌症治疗平台提供了前所未有的机会。与在生物流体中表现出布朗运动的普通纳米粒子不同，MNR 通过有效的自推进克服了超低雷诺数 (Re << 1) 环境中的粘性阻力。这种独特的运动特性推动了 MNR 的先进设计和功能化，作为下一代癌症治疗平台的基础，为精确分布和改善治疗药物的渗透提供了潜力。增强屏障穿透，影像引导操作，此外还研究了生物传感，以实现 MNR 的有前途的癌症相关应用。在此，全面介绍了基于 MNR 的癌症治疗的最新进展，包括驱动引擎、诊断、医学成像和靶向药物输送；强调了未来十年可能对癌症治疗产生深远影响的有前途的研究机会。

更新日期：2022-04-06

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