The current study investigated the effects of dietary curcumin nanoparticles (C-NPs) on the performance, hemato-biochemical profile, digestive enzymes activities, antioxidant status, humoral immunity, and liver and intestinal histology of Nile tilapia (Oreochromis niloticus). Fish (4.3 ± 0.5 g) were fed with diets enriched with 0.0 (control), 15, 30, 45, and 60 mg C-NPs/kg diet up to apparent satiety thrice a day for 60 days. The growth-stimulating effects of dietary C-NPs were significantly observed in terms of final weight, weight gain %, specific growth rate, and feed intake. Compared with the control group, serum amylase, lipase, and proteases activities of Nile tilapia significantly (P < 0.05) increased alongside the increase in dietary levels of C-NPs in a dose-dependent manner. The counts of red blood cells and white blood cells as well as hemoglobin and hematocrit levels of Nile tilapia fed with 30–60 mg C-NPs/kg diet were statistically (P < 0.05) higher than fish in the control group with no significant differences among them (P > 0.05). Moreover, lymphocytes and monocytes significantly (P > 0.05) increased; meanwhile neutrophils significantly (P > 0.05) decreased as C-NPs levels in diets increased. In a similar trend, antioxidant (malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase) and humoral immunity (lysozyme and total immunoglobulin) biomarkers were significantly higher in C-NPs-fed fish. Liver histology showed improvements in the cell architecture of fish fed with C-NPs containing diets up to 45 mg/kg diet. Compared with the control diet, feeding Nile tilapia with C-NPs diets resulted in a higher villi length/width and absorption area. According to the regression curves, the current study recommends using the dietary C-NP with optimum values of 45–55 mg/kg diet to improve the performance, digestive enzymes, antioxidant activities, and immunity response of Nile tilapia.

目前的研究调查了膳食姜黄素纳米粒子 (C-NPs) 对尼罗罗非鱼 ( Oreochromis niloticus )的性能、血液生化特征、消化酶活性、抗氧化状态、体液免疫以及肝脏和肠道组织学的影响。用富含 0.0（对照）、15、30、45 和 60 mg C-NPs/kg 日粮的日粮喂养鱼（4.3 ± 0.5 g），每天三次达到明显饱腹感，持续 60 天。日粮 C-NPs 的生长刺激作用在终重、增重 %、比生长速率和采食量方面均得到显着观察。与对照组相比，尼罗罗非鱼血清淀粉酶、脂肪酶和蛋白酶活性显着( P< 0.05) 随着膳食中 C-NPs 水平的增加而增加，呈剂量依赖性。饲喂30~60 mg C-NPs/kg日粮的尼罗罗非鱼红细胞和白细胞计数、血红蛋白和血细胞比容水平均高于对照组（ P < 0.05），差异无统计学意义。其中（P > 0.05）。此外，淋巴细胞和单核细胞显着增加（P > 0.05）；同时中性粒细胞显着 ( P> 0.05) 随着日粮中 C-NPs 水平的增加而降低。在类似的趋势中，C-NPs 喂养的鱼的抗氧化剂（丙二醛、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶）和体液免疫（溶菌酶和总免疫球蛋白）生物标志物显着升高。肝脏组织学显示，喂食含有高达 45 mg/kg 饮食的 C-NPs 的鱼的细胞结构有所改善。与对照日粮相比，C-NPs日粮饲喂尼罗罗非鱼的绒毛长度/宽度和吸收面积更高。根据回归曲线，目前的研究建议使用最佳值为 45-55 mg/kg 日粮的 C-NP 日粮以改善尼罗罗非鱼的生产性能、消化酶、抗氧化活性和免疫反应。